The journalist and presenter examines why pleasure and pain are integral to human survival, submitting himself to some of the most extreme forms of both sensations. He reveals how the hottest chilli in the world creates a sense of euphoria in the brain, and explains the biological reasons why parents feel a surge of love for newborn children. He also exposes himself to painful experiments, highlighting the dangers of life without discomfort and discovering how far he is prepared to go to experience one of the world's most pleasurable highs.