In the late 1980s the Arellano-Felix brothers take over the Tijuana Cartel. Using a network of tunnels, modified cars, boats and planes they flood the US with billions of dollars worth of drugs; quickly establishing themselves as the worlds largest smugglers of cocaine.

To protect this business the brothers recruit and train an army of American gang bangers. When rival cartels attempt to muscle in on their business the result is a war that claims thousands of lives.

Mexican and US law enforcement join forces to take the Brothers down but they're powerless to stop a wave of violence engulfing Tijuana.